Polymorphism rs143384 GDF5 reduces the risk of knee osteoarthritis development in obese individuals and increases the disease risk in non-obese population.

Vitaly NovakovOlga NovakovaMaria ChurnosovaInna AristovaMarina PonomarenkoYuliya ReshetnikovaVladimir ChurnosovInna SorokinaIrina PonomarenkoOlga EfremovaValentina OrlovaIrina BatlutskayaAlexey PolonikovEvgeny ReshetnikovMikhail Churnosov

Published in: Arthroplasty (London, England) (2024)

In summary, the effect of obesity on the association of the rs143384 GDF5 with KOA was shown: the "protective" value of this polymorphism in the BMI ≥ 30 group and the "risk" meaning in BMI < 30 cohort.

Keyphrases

knee osteoarthritis
weight loss
metabolic syndrome
type diabetes
weight gain
adipose tissue
body mass index
bariatric surgery
palliative care