Login / Signup

Heme-Mimetic Photosensitizer with Iron-Targeting and Internalizing Properties for Enhancing PDT Activity and Promoting Infected Diabetic Wound Healing.

Jiawei BaoJiayu MiYi XiaHan GuiHaixue JiaDianyu WangHongjing LuoLinzhu SuJiamin ZhangJinjian LiuJianfeng Liu
Published in: ACS applied bio materials (2024)
The management of multibacterial infections remains clinically challenging in the care and treatment of chronic diabetic wounds. Photodynamic therapy (PDT) offers a promising approach to addressing bacterial infections. However, the limited target specificity and internalization properties of traditional photosensitizers (PSs) toward Gram-negative bacteria pose significant challenges to their antibacterial efficacy. In this study, we designed an iron heme-mimetic PS (MnO 2 @Fe-TCPP(Zn)) based on the iron dependence of bacteria that can be assimilated by bacteria and retained in different bacteria strains ( Escherichia coli , Staphylococcus aureus , and methicillin-resistant Staphylococcus aureus ) and which shows high PDT antibacterial efficacy. For accelerated wound healing after antibacterial treatment, MnO 2 @Fe-TCPP(Zn) was loaded into a zwitterionic hydrogel with biocompatibility and antifouling properties to form a nanocomposite antibacterial hydrogel (PSB-MnO 2 @Fe-TCPP(Zn)). In the multibacterial infectious diabetic mouse wound model, the PSB-MnO 2 @Fe-TCPP(Zn) hydrogel dressing rapidly promoted skin regeneration by effectively inhibiting bacterial infections, eliminating inflammation, and promoting angiogenesis. This study provides an avenue for developing broad-spectrum antibacterial nanomaterials for combating the antibiotic resistance crisis and promoting the healing of complex bacterially infected wounds.
Keyphrases