Heme-Mimetic Photosensitizer with Iron-Targeting and Internalizing Properties for Enhancing PDT Activity and Promoting Infected Diabetic Wound Healing.
Jiawei BaoJiayu MiYi XiaHan GuiHaixue JiaDianyu WangHongjing LuoLinzhu SuJiamin ZhangJinjian LiuJianfeng LiuPublished in: ACS applied bio materials (2024)
The management of multibacterial infections remains clinically challenging in the care and treatment of chronic diabetic wounds. Photodynamic therapy (PDT) offers a promising approach to addressing bacterial infections. However, the limited target specificity and internalization properties of traditional photosensitizers (PSs) toward Gram-negative bacteria pose significant challenges to their antibacterial efficacy. In this study, we designed an iron heme-mimetic PS (MnO 2 @Fe-TCPP(Zn)) based on the iron dependence of bacteria that can be assimilated by bacteria and retained in different bacteria strains ( Escherichia coli , Staphylococcus aureus , and methicillin-resistant Staphylococcus aureus ) and which shows high PDT antibacterial efficacy. For accelerated wound healing after antibacterial treatment, MnO 2 @Fe-TCPP(Zn) was loaded into a zwitterionic hydrogel with biocompatibility and antifouling properties to form a nanocomposite antibacterial hydrogel (PSB-MnO 2 @Fe-TCPP(Zn)). In the multibacterial infectious diabetic mouse wound model, the PSB-MnO 2 @Fe-TCPP(Zn) hydrogel dressing rapidly promoted skin regeneration by effectively inhibiting bacterial infections, eliminating inflammation, and promoting angiogenesis. This study provides an avenue for developing broad-spectrum antibacterial nanomaterials for combating the antibiotic resistance crisis and promoting the healing of complex bacterially infected wounds.
Keyphrases
- wound healing
- photodynamic therapy
- staphylococcus aureus
- escherichia coli
- methicillin resistant staphylococcus aureus
- heavy metals
- healthcare
- stem cells
- palliative care
- oxidative stress
- biofilm formation
- type diabetes
- gold nanoparticles
- drug delivery
- pseudomonas aeruginosa
- signaling pathway
- metal organic framework
- cystic fibrosis
- visible light
- combination therapy
- reduced graphene oxide
- iron deficiency
- quantum dots
- highly efficient
- vascular endothelial growth factor
- quality improvement
- affordable care act