Quetiapine dose optimisation during gestation: a pharmacokinetic modelling study.

Published in: The Journal of pharmacy and pharmacology (2020)

Quetiapine doses in pregnancy should be increased to 500-700 mg twice daily to counteract a concomitant increase in metabolic clearance, increase in volume of distribution and decrease in plasma protein binding.

Keyphrases

preterm infants
preterm birth
binding protein
physical activity
protein protein
pregnancy outcomes
gestational age