TSPO imaging using the novel PET ligand [18F]GE-180: quantification approaches in patients with multiple sclerosis.
Lena KaiserNathalie Lisa AlbertSimon LindnerMarcus UnterrainerChristoph MahlerMatthias BrendelLarissa ErmoschkinAstrid GosewischAnika BrunegrafChristopher BuckleyTania KümpfelRainer RupprechtSibylle ZieglerMartin KerschensteinerPeter BartensteinGuido BöningPublished in: EJNMMI research (2017)
This comparison with parameters from dynamic data suggests that SUVR normalised to corrected frontal cortex as PRR is suitable for the quantification of [18F]GE-180 uptake in lesions and different brain regions of RRMS patients. This efficient diagnostic protocol based on static [18F]GE-180 PET scans acquired 60-90 min p.i. allows the semi-quantitative assessment of neuroinflammation in RRMS patients in clinical routine.
Keyphrases
- pet imaging
- positron emission tomography
- end stage renal disease
- newly diagnosed
- ejection fraction
- computed tomography
- chronic kidney disease
- peritoneal dialysis
- high resolution
- traumatic brain injury
- magnetic resonance imaging
- magnetic resonance
- clinical practice
- electronic health record
- photodynamic therapy
- brain injury
- patient reported
- contrast enhanced