Cytotoxic T cell depletion with increasing epithelial abnormality in women with benign breast disease.
Sabina AdhikaryTanya L HoskinMelody L Stallings-MannMuhammad ArshadMarlene H FrostStacey J WinhamAlvaro PeñaDelphine J LeeLinda M MurphyMichele RakoffLori A DenisonKeith L KnutsonDerek C RadiskyDaniel W VisscherAmylou C DueckPublished in: Breast cancer research and treatment (2020)
In women with BBD, breast lobules with increasing epithelial abnormality show significant decreases in cytotoxic T cells as measured by CD8/CD103 staining, suggesting that impaired immunosurveillance may be a component of the earliest stages of breast cancer development.
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