Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer.

Andrew T Lenis Vignesh Ravichandran Samantha Brown Syed M Alam Andrew Katims Hong Truong Peter A Reisz Samantha Vasselman Barbara Nweji Karen A Autio Michael J Morris Susan F Slovin Dana E Rathkopf Daniel Costin Danila Sungmin Woo Hebert Alberto Vargas Vincent P Laudone Behfar Ehdaie Victor Reuter Maria E Arcila Michael F Berger Agnes Viale Howard I Scher Nikolaus Schultz Anuradha Gopalan Mark T A Donoghue Irina Ostrovnaya Konrad H Stopsack David B Solit Wassim Abida

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

MSI-H/dMMR prostate cancers have greater TMB, indel, and neoantigen burden than TMB-H/MSS prostate cancers, and these differences may contribute to profound and durable responses to ICB.

Keyphrases

prostate cancer
radical prostatectomy

benign prostatic hyperplasia
risk factors

intellectual disability
young adults

autism spectrum disorder
childhood cancer