Adoptive Transfer of JC Virus-Specific T Lymphocytes for the Treatment of Progressive Multifocal Leukoencephalopathy.
Giulia BerzeroSabrina BassoLuca StoppiniAndrea PalermoAnna PichiecchioMatteo PaolettiFederica LucevSimonetta GereviniAndrea RossiElisa VegezziLuca DiamantiPaola BiniMatteo GastaldiSerena DelbueCesare PerottiElena SeminariMaura FaraciMario LuppiFausto BaldantiMarco ZeccaEnrico MarchioniPatrizia ComoliPublished in: Annals of neurology (2021)
Among other novel treatments, T cell therapy is emerging as a viable treatment option in patients with PML, particularly for those not amenable to restoration of specific immunity. Neurologists should be encouraged to refer PML patients to specialized centers to allow access to this treatment strategy. ANN NEUROL 2021;89:769-779.