Effects of phosphodiesterase-1 inhibitor on pulmonary vein electrophysiology and arrhythmogenesis.
Dony YugoYao-Chang ChenShih-Ann ChenChih-Min LiuJen Hung HuangShih-Ann ChenYi-Jen ChenPublished in: European journal of clinical investigation (2021)
ITI-214 reduces PV spontaneous activity and PV diastolic tension by reducing INa-Late , ICa-L and NCX current. Considering its therapeutic potential in heart failure, targeting PDE-1 inhibition may provide a novel strategy for managing atrial arrhythmogenesis.