A positive feedback loop of heparanase/syndecan1/nerve growth factor regulates cancer pain progression.

Xiaohu Su Bingwu Wang Zhaoyun Zhou Zixian Li Song Tong Simin Chen Nan Zhang Su Liu Maoyin Zhang

Published in: The Korean journal of pain (2022)

The results showed that HPSE promoted melanoma development and cancer pain by interacting with NGF/SDC1. It provides new insights to better understand the role of HPSE in melanoma and also provides a new direction for cancer pain treatment.

Keyphrases

growth factor
papillary thyroid
chronic pain
squamous cell
pain management
neuropathic pain
squamous cell carcinoma
lymph node metastasis
spinal cord
postoperative pain