Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver.
Caroline SchmittH LengletA YuC DelabyA BeneckeT LefebvreP LetteronV ParadisS WahlinS SandbergP HarperE SardhA K SandvikJ R HovA K AarsandL ChicheC BazilleJ-Y ScoazecJ To-FiguerasM CarrascalJ AbianA MirmiranZ KarimJ-C DeybachH PuyK Peoc'hH ManceauL GouyaPublished in: Journal of internal medicine (2018)
Altogether, this study has important impacts on AIP care underlying that hemin needs to be restricted to severe neurovisceral crisis and suggests that alternative treatment targeting the liver such as ALAS1 and HO1 inhibitors, and anti-inflammatory therapies should be considered in patients with recurrent AIP.