Cytotoxic Spliceostatin Analogs from Pseudomonas sp.
Hong ZhaoBei ZhangLie-Feng MaLin-Mei ShiZha-Jun ZhanPublished in: Chemistry & biodiversity (2019)
Two new spliceostatin analogs, designed as spliceostatins J and K (1 and 2), were isolated and identified from the culture of Pseudomonas sp., along with two known ones, FR901464 (3) and spliceostatin E (4). Their structures were elucidated by detailed interpretation of their spectroscopic data, especially 2D-NMR and HR-ESI-MS. Spliceostatin J (1) represented the first example of spliceostatins bearing an unusual hexahydrofuro[3,4-b]furan moiety. Biological assay showed all the isolated compounds except 1 displayed potent cytotoxic activities against two cancer cell lines (MDA-MB-231 and A-549). Structure-activity-relationship studies revealed that the tetrahydropyran ring in spliceostatin analogs was necessary for their bioactive retention.
Keyphrases
- molecular docking
- ms ms
- structure activity relationship
- high resolution
- papillary thyroid
- magnetic resonance
- multiple sclerosis
- biofilm formation
- molecular dynamics simulations
- high throughput
- electronic health record
- squamous cell carcinoma
- single cell
- breast cancer cells
- big data
- machine learning
- cell death
- signaling pathway
- solid state
- pseudomonas aeruginosa
- cystic fibrosis
- anti inflammatory
- lymph node metastasis
- young adults
- artificial intelligence