Statin-induced autoimmune myopathy: a case report.
Natalia Alzueta IsturizMarta MarinMarta CastresanaAna GascónMaría PíoMaría Jesús IguzquizaPublished in: European journal of hospital pharmacy : science and practice (2019)
Statins are widely used in the treatment of hypercholesterolemia. Muscle weakness and elevated creatine kinase (CK) are frequent side effects of statins with an incidence of about 15%. Statin-associated myopathy is more common in people who receive multiple drugs, the elderly or women but the mechanism underlying it is still unclear. These symptoms generally improve after drug discontinuation. However, there is a type of autoimmune mediated myopathy characterised by the persistence of muscle weakness and CK elevation after stopping statins. Herein, we discuss a case of autoimmune myopathy associated with statin exposure and responsive to immunossupresive drugs. The increased use of statins in recent years raises the importance of acquaintance with this disease in clinical practice.
Keyphrases
- cardiovascular disease
- drug induced
- late onset
- muscular dystrophy
- multiple sclerosis
- protein kinase
- clinical practice
- coronary artery disease
- cardiovascular events
- skeletal muscle
- low density lipoprotein
- early onset
- type diabetes
- myasthenia gravis
- polycystic ovary syndrome
- risk factors
- diabetic rats
- middle aged
- oxidative stress
- insulin resistance
- tyrosine kinase
- adipose tissue
- drug delivery
- combination therapy
- smoking cessation
- breast cancer risk