Identification of the immune checkpoint signature of multiple myeloma using mass cytometry-based single-cell analysis.

Jinheng WangYongjiang ZhengChenggong TuHui ZhangKarin VanderkerkenEline MenuJinbao Liu

Published in: Clinical & translational immunology (2020)

A clear interaction between MM cells and the surrounding immune cells was established, leading to immune checkpoint dysregulation. The analysis of the immune landscape enhances our understanding of the MM immunological milieu and proposes novel targets for improving immune checkpoint blockade-based MM immunotherapy.

Keyphrases

single cell
rna seq
multiple myeloma
induced apoptosis
high throughput
cell cycle arrest
cell death
signaling pathway
cell proliferation
bioinformatics analysis
pi k akt