Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy.
Marco LucianiMontalbano MauroLuca TronconeCamilla BacchinKeita UchidaGianlorenzo DanieleBethany J WolfHelen M ButlerJustin KielStefano BertoCortney GensemerKelsey S MooreJordan E MorningstarThamonwan DiteepengOnder AlbayramJose Francisco AbisambraRussell A NorrisThomas G Di SalvoBenjamin L ProsserRakez KayedFederica Del MontePublished in: European heart journal (2023)
The study presents new mechanistic evidence and potential treatment for the brain-heart tauopathy axis in myocardial and brain degenerative diseases and ageing.
Keyphrases
- left ventricular
- resting state
- white matter
- heart failure
- small molecule
- blood pressure
- functional connectivity
- oxidative stress
- high throughput
- cerebral ischemia
- cerebrospinal fluid
- stem cells
- multiple sclerosis
- machine learning
- replacement therapy
- mesenchymal stem cells
- risk assessment
- blood brain barrier
- artificial intelligence
- combination therapy