Effect of Single-Dose and Short-Term Administration of Si Jun Zi Tang on the Pharmacokinetics of Gefitinib in Rats.
Ying LiXiaowei ZhouMing NiuMingyu ZhangQiong GuWei ChenBin DongYuanyuan ZhangRuisheng LiChunyu LiGuohui LiPublished in: Evidence-based complementary and alternative medicine : eCAM (2021)
Potential pharmacokinetic interactions between gefitinib and SJZ were evaluated, and SJZ extended T max and T1/2 and increased the C max and AUC of gefitinib. Long-term administration of gefitinib in combination with Si Jun Zi Tang would improve the efficacy of gefitinib.