Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI.

J Scott McNallyAdam H de HavenonSeong-Eun KimChuanzhuo WangShuping WangMatthew S ZabriskieDennis L ParkerHediyeh BaradaranMatthew David Alexander

Published in: The neuroradiology journal (2020)

Intracranial atherosclerotic disease can be reliably produced and detected using 3T vessel wall magnetic resonance imaging-compatible Watanabe heritable hyperlipidemic and ApoE rabbit models. Further analysis is needed to characterize better the development and progression of the disease to correlate tissue-validated animal findings with those in human vessel wall magnetic resonance imaging studies.

Keyphrases

magnetic resonance imaging
contrast enhanced
computed tomography
endothelial cells
type diabetes
diffusion weighted imaging
metabolic syndrome
optical coherence tomography
mild cognitive impairment