Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-κB/bone remodeling factors signaling.

Yingru XuShuxia ZhangXinyi LiaoMan LiSuwen ChenXincheng LiXingui WuMeisongzhu YangMiaoling TangYameng HuZiwen LiRuyuan YuMudan HuangLibing SongJun Li

Published in: Molecular cancer (2021)

We revealed a plausible mechanism for circIKBKB-mediated NF-κB hyperactivation in bone-metastatic BC, which might represent a potential strategy to treat breast cancer bone metastasis.

Keyphrases

bone mineral density
soft tissue
signaling pathway
bone loss
bone regeneration
squamous cell carcinoma
lps induced
postmenopausal women
body composition
pi k akt
immune response
inflammatory response
risk assessment