Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study.

Florian UhleChristoph LichtensternThorsten Brenner Thomas FlemingChristian KochAndreas HeckerChristian HeissPeter Paul NawrothStefan HoferMarkus Alexander WeigandKatja Weismüller

Published in: Mediators of inflammation (2015)

Our results provide evidence for a persisting activation of the RAGE axis while classical mediators like IL-6 disappear early. Considering the immunocompromised phenotype of the monocytes, the RAGE ligands might be substantial contributors to the well-known secondary stage of impaired immune responsiveness in trauma patients.

Keyphrases

trauma patients
immune response
dendritic cells
peripheral blood
intensive care unit
drug induced