Node-negative colon cancer: histological, molecular, and stromal features predicting disease recurrence.
Maud T A StrousRagna L A van der LindenAudrey L H M GubbelsTimothy K E FaesKoop BosschaCarolien M BronkhorstMaryska L G Janssen-HeijnenAdriaan P de BruïneF Jeroen VogelaarPublished in: Molecular medicine (Cambridge, Mass.) (2023)
Judging by the higher HR for the combination of the prognostic factors TSR and BRAF compared to the HRs of these prognostic factors individually, the prognostication for disease free survival can be improved by determining both TSR and BRAF instead of BRAF alone, as is done in current daily practise. In this study MSI also shows additional value to TSR in the prognostication of disease free survival. Adopting TSR into daily diagnostics will be of additional value next to currently used molecular markers in risk stratification of patients with node negative colon cancer and is therefore advised.