Early posttransplant reductions in club cell secretory protein associate with future risk for chronic allograft dysfunction in lung recipients: results from a multicenter study.

Jamie L ToddJeremy M WeberFrancine L KellyMegan L NeelyAndrew NaglerDylan CarmackCourtney W FrankelDavid M BrassJohn A BelperioMarie M BudevMatthew G HartwigTereza MartinuJohn M ReynoldsPali D ShahLianne G SingerLaurie D SnyderS Sam WeigtScott M Palmer

Published in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (2023)

We discovered a threshold for reduced BALF CCSP to discriminate future CLAD risk; supporting the utility of BALF CCSP as a tool for early posttransplant risk stratification. Additionally, our finding that low CCSP associates with future CLAD underscores a role for club cell injury in CLAD pathobiology.

Keyphrases

current status
single cell
cell therapy
kidney transplantation
mesenchymal stem cells
protein protein
small molecule
bone marrow
amino acid