Heterogeneity-induced NGF-NGFR communication inefficiency promotes mitotic spindle disorganization in exhausted T cells through PREX1 suppression to impair the anti-tumor immunotherapy with PD-1 mAb in hepatocellular carcinoma.

Xin WangTongwang YangShangheng ShiChuanshen XuFeng WangDeshu DaiGe GuanYong ZhangShuxian WangJianhong WangBingliang ZhangPeng LiuXiaoshuai BaiYan JinXinqiang LiCunle ZhuDexi ChenQingguo XuYuan Guo

Published in: Cancer medicine (2024)

Inefficiency in NGF-NGFR communication impairs PD-1 mAb immunotherapy and could thus be utilized as a novel therapeutic target in the treatment of HCC patients in clinical practice.

Keyphrases

clinical practice
end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
high glucose
single cell
patient reported outcomes
diabetic rats
drug induced
replacement therapy