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Heme-Inducing Endothelial Pyroptosis Plays a Key Role in Radiofrequency Ablation of Hepatic Hemangioma Leading to Systemic Inflammatory Response Syndrome.

Changyu YaoJian KongFei XuShaohong WangShilun WuWenbing SunJun Gao
Published in: Journal of inflammation research (2024)
Our findings suggest that heme induces endothelial cell pyroptosis and SIRS in mice and decreasing heme levels and ROS scavengers may prevent SIRS in hepatic hemangioma after RFA.
Keyphrases
  • radiofrequency ablation
  • inflammatory response
  • endothelial cells
  • nlrp inflammasome
  • dna damage
  • lipopolysaccharide induced
  • reactive oxygen species
  • high fat diet induced
  • toll like receptor
  • oxidative stress