Uncovering key targets of success for immunotherapy in pancreatic cancer.

Andrea PrettaEleonora LaiMara PersanoClelia DonisiGiovanna PinnaErika CimbroAlissa ParrinoDario SpanuStefano MarianiNicole LisciaMarco DuboisMarco MigliariValentino ImperaGiorgio SabaValeria PuscedduMarco PuzzoniPina ZiranuMario Scartozzi

Published in: Expert opinion on therapeutic targets (2021)

The tumour microenvironment is a critical variable of treatment resistance because of its role as a physical barrier and inhibitory immune signalling. Promising therapeutic strategies appear to be a combination of immunotherapeutics with other targeted treatments. Going forward, predictive biomarkers are required to improve patient selection. Biomarker-driven trials could enhance approaches for assessing the role of immunotherapy in PDAC.

Keyphrases

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