A novel infram deletion in MSH6 gene in glioma: Conversation on MSH6 mutations in brain tumors.

Zeinab Deris ZayeriMaryam Tahmasebi BirganiJavad Mohammadi AslDavood KashipazhaMohammadreza Hajjari

Published in: Journal of cellular physiology (2018)

Patients should be evaluated for MMR mutation before chemo and radiotherapy, and it is valuable to follow-up these mutations during the treatment too. In temozolomide (TMZ)-resitance cases, it is suggested to use complementary strategies such as using HDACis and a combination of a STAT3 Inhibitor and an mTOR inhibitor, BER inhibition mechanism, and PARP-1 inhibitor.

Keyphrases

newly diagnosed
end stage renal disease
ejection fraction
cell proliferation
chronic kidney disease
early stage
prognostic factors
dna damage
photodynamic therapy
locally advanced
copy number
dna repair
genome wide
patient reported outcomes
gene expression
smoking cessation
cancer therapy