CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice.

Shimon OtakeTomoyuki SasakiToshiaki ShiraiNagaharu TsukijiShogo TamuraKatsuhiro TakanoYukio OzakiKatsue Suzuki-Inoue

Published in: Journal of thrombosis and haemostasis : JTH (2021)

Our findings suggest that IGF-1 secretion from PDPN-expressing stromal cells by CLEC-2 stimulation positively regulates erythroblasts. This novel mechanism of erythropoiesis regulation indicates that a microenvironment consisting of megakaryocytes and PDPN-expressing stromal cells supports erythropoiesis.

Keyphrases

stem cells
pi k akt
binding protein
wild type
growth hormone
high fat diet induced
adipose tissue
metabolic syndrome