CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice.
Shimon OtakeTomoyuki SasakiToshiaki ShiraiNagaharu TsukijiShogo TamuraKatsuhiro TakanoYukio OzakiKatsue Suzuki-InouePublished in: Journal of thrombosis and haemostasis : JTH (2021)
Our findings suggest that IGF-1 secretion from PDPN-expressing stromal cells by CLEC-2 stimulation positively regulates erythroblasts. This novel mechanism of erythropoiesis regulation indicates that a microenvironment consisting of megakaryocytes and PDPN-expressing stromal cells supports erythropoiesis.