DNA-PK Inhibitor Peposertib Amplifies Radiation-Induced Inflammatory Micronucleation and Enhances TGFβ/PD-L1 Targeted Cancer Immunotherapy.
Michael I CarrLi-Ya ChiuYige GuoChunxiao XuAdam S LazorchakHuakui YuGuozhong QinJin QiBo MarelliYan LanQing SunFrank CzaudernaFrank T ZenkeAndree BlaukatLyubomir T VassilevPublished in: Molecular cancer research : MCR (2022)
Selective inhibition of DNA-PK in irradiated cancer cells enhances inflammatory signaling and activity of dual TGFβ/PD-L1 targeted therapy and may offer a more efficacious combination option for the treatment of locally advanced solid tumors.