Genetic Susceptibility to Chronic Kidney Disease: Links, Risks and Management.

Hanny SawafTariku T GuduraSylvester DorobiszDianne SandyXiangling WangShane A Bobart

Published in: International journal of nephrology and renovascular disease (2023)

Chronic kidney disease (CKD) is associated with significant morbidity and mortality worldwide. In recent years, our understanding of genetic causes of CKD has expanded significantly with several renal conditions having been identified. This review discusses the current landscape of genetic kidney disease and their potential treatment options. This review will focus on cystic kidney disease, glomerular disease with genetic associations, congenital anomalies of kidneys and urinary tract (CAKUT), autosomal dominant-tubulointerstitial kidney disease (ADTKD), inherited nephrolithiasis and nephrocalcinosis.

Keyphrases

chronic kidney disease
end stage renal disease
genome wide
copy number
urinary tract
human health
gene expression
climate change