Early-life cytomegalovirus infection is associated with gut microbiota perturbations and increased risk of atopy.
Hind SbihiKaren E SimmonsMalcolm R SearsTheo J MoraesAllan B BeckerPiush J MandhanePadmaja SubbaraoDarlene L Y DaiB Brett FinlaySuzanne C ToughSoren GanttPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2021)
Early-life CMV infection is associated with an alteration in the intestinal microbiota, which mediates the effect of the infection on childhood atopy. This work indicates that preventing CMV infection would not put children at increased risk of developing atopy. Rather, a CMV vaccine, in addition to preventing CMV-associated morbidity and mortality, might reduce the risk of childhood allergic diseases.
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