Plasmatic HIV-1 soluble gp120 is associated with immune dysfunction and inflammation in ART-treated individuals with undetectable viremia.

Mehdi BenlarbiJonathan RichardCatherine BourassaWilliam D TolbertCarl Chartrand-LefebvreGabrielle Gendron-LepageMohamed SyllaMohamed El-FarMarc Messier-PeetCamille GuertinIsabelle TurcotteRémi FromentinMyriam Maude VerlyJérémie PrévostAndrew ClarkWalther MothesDaniel E KaufmannFrank MaldarelliNicolas ChomontPhilippe BéginNicolas ChomontJean-Guy BarilBenoit TrottierSylvie TrottierRalf DuerrMarzena PazgierMadeleine DurandAndrés Finzinull nullnull null

Published in: medRxiv : the preprint server for health sciences (2023)

Soluble gp120 is detected in the plasma of people living with HIV-1 with undetectable viremia. The presence of soluble gp120 and anti-cluster A antibodies is associated with immune dysfunction, chronic inflammation, and sub-clinical cardiovascular disease.

Keyphrases

oxidative stress
cardiovascular disease
antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
hepatitis c virus
hiv testing
metabolic syndrome
cardiovascular risk factors
coronary artery disease
drug induced