Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine.

Yang Sun Sofia Rodríguez-Rangel Lauren L Zhang Jorge E Sánchez-Rodríguez Pedro Brugarolas

Published in: bioRxiv : the preprint server for biology (2023)

. The results indicate that 5-methyl-3F4AP exhibits high binding affinity, good physicochemical properties and slower oxidation by CYP2E1 than 3F4AP, making it a promising candidate for further PET studies.

Keyphrases

positron emission tomography
transcription factor
computed tomography
pet ct
dna binding
hydrogen peroxide
case control
pet imaging
angiotensin converting enzyme
binding protein
nitric oxide
angiotensin ii