Novel small-molecule compound YH7 inhibits the biofilm formation of Staphylococcus aureus in a sarX -dependent manner.
Yanghua XiaoCailing WanXiaocui WuYanlei XuYao ChenLulin RaoBingjie WangLi ShenWeihua HanHuilin ZhaoJunhong ShiJiao ZhangZengqiang SongFangyou YuPublished in: mSphere (2024)
. Notably, its exceptional efficacy against both methicillin-resistant and methicillin-susceptible strains highlights its broad applicability. This study highlights the potential of YH7 as a novel therapeutic agent to address the pressing issue of biofilm-driven infections.