Analysis of CDR1 and MDR1 Gene Expression and ERG11 Substitutions in Clinical Candida tropicalis Isolates from Alexandria, Egypt.

Mohammed A El-KholyGhada F HelalyEbtisam F El GhazzawiGamal El-SawafSherine M Shawky

Published in: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] (2023)

This study has highlighted the role of overexpression of the CDR1 gene and ERG11 gene mutations in fluconazole non-susceptibility. Further studies in Egypt are required to investigate other possible molecular mechanisms involved in azole resistance.

Keyphrases

candida albicans
gene expression
dna methylation
biofilm formation
cell proliferation
genome wide
copy number
transcription factor
staphylococcus aureus
cystic fibrosis