Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone).
Tomomi MasudaMasamitsu ShimazawaHideaki HaraPublished in: Oxidative medicine and cellular longevity (2017)
Oxidative stress plays a pivotal role in developing and accelerating retinal diseases including age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), and retinal vein occlusion (RVO). An excess amount of reactive oxygen species (ROS) can lead to functional and morphological impairments in retinal pigment epithelium (RPE), endothelial cells, and retinal ganglion cells (RGCs). Here we demonstrate that edaravone, a free radical scavenger, decreased apoptotic cell death, oxidative damage to DNA and lipids, and angiogenesis through inhibiting JNK and p38 MAPK pathways in AMD, glaucoma, DR, and RVO animal models. These data suggest that the therapeutic strategy for targeting oxidative stress may be important for the treatment of these ocular diseases, and edaravone may be useful for treating retinal diseases associated with oxidative stress.
Keyphrases
- diabetic retinopathy
- oxidative stress
- cell death
- induced apoptosis
- optical coherence tomography
- optic nerve
- age related macular degeneration
- endothelial cells
- dna damage
- reactive oxygen species
- cell cycle arrest
- signaling pathway
- diabetic rats
- ischemia reperfusion injury
- endoplasmic reticulum stress
- single molecule
- pi k akt
- vascular endothelial growth factor
- heat shock
- data analysis
- cataract surgery