Encapsulated Checkpoint Blocker Before Chemotherapy: The Optimal Sequence of Anti-CTLA-4 and Doxil Combination Therapy.

Reza AlimohammadiRazieh AlibeigiAmin Reza NikpoorGhanbar Mahmoodi ChalbataniThomas Jay Webster Mahmoud Reza JaafariSeyed Amir Jalali

Published in: International journal of nanomedicine (2020)

In summary, our results demonstrate the potential of utilizing a nanocarrier system for the delivery of checkpoint blockers, such as anti-CTLA-4 which further showed potential in a combination therapy, especially when administered before chemotherapy.

Keyphrases

combination therapy
dna damage
cell cycle
locally advanced
angiotensin converting enzyme
drug delivery
human health
squamous cell carcinoma
oxidative stress
cell proliferation
climate change
angiotensin ii