Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage.
Zhangjian ZhouHeng LuShoumin ZhuAhmed GomaaZheng ChenJin YanKay WashingtonWael El-RifaiChengxue DangDunfa PengPublished in: Journal of experimental & clinical cancer research : CR (2019)
IGFBP2 protects EAC cells against ABS-induced DNA damage and apoptosis through stabilization and activation of EGFR - DNA-PKcs signaling axis.