Evaluation of a modular all-in-one high-resolution PET detector and readout electronics setup.

Objective
The all-in-one solution and modularity of the C13500 series TOF-PET detector modules (Hamamatsu Photonics K.K., Hamamatsu, Japan) make them a highly attractive candidate for the development of positron emission tomography (PET) systems. However, the commercially available portfolio targets clinical whole-body PET systems with a scintillation crystal cross area of 3.1×3.1 mm3. To extend the modules for high resolution (preclinical or organ specific) systems, the support for smaller scintillation crystals is required.
Approach
In this work, a PET detector was developed based on the TOF-PET modules using a light sharing approach, 16×16 lutetium oxyorthosilicate (LSO) scintillation crystals with a size of 1.51×1.51×10.00 mm3 readout with 8×8 photosensor channels of size 3.0×3.0 mm2. In addition to hardware and software development, the optimized parameter settings for the adapted configuration were evaluated. 
Main Results
A factor of two in amplification of the analog signal compared to the minimum gain setting was necessary for an accurate crystal identification (peak-to-valley ratio 14.9±5.9). A further increase to a factor of three was not determined as optimum as the time over threshold duration, thus pile-up probability, increased from 1032.1±109.5 ns to 1789.5±218.5 ns (photopeak position). With this amplification a full width at half maximum (FWHM) energy resolution of 14.1±2.0 % and a high linearity of the energy detection was obtained. 
A FWHM coincidence resolving time (CRT) of 313 ps was achieved by using a low timing threshold, increasing the bandwidth of the front-end circuit and using a narrow ±1σ energy window. To approximately double the sensitivity and reduce the power consumption, the timing parameters were adjusted resulting in a FWHM CRT of 354 ps (±2σ). 
Significance
Based on the results obtained with the proof-of-concept detector setup, we confirm the modularity and flexibility of the all-in-one TOF-PET detector modules for the future development of application-specific high-resolution PET systems.&#xD.