Role of Pharmacogenomics in the Efficacy and Safety of Thiopurines in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.

Marta Gutiérrez-ValenciaLeire LeacheLuis Carlos SaizJuan J BeloquiMiguel BarajasMiren VicuñaJuan Erviti

Published in: Journal of clinical gastroenterology (2022)

Mutations in TPMT and NUDT15 genes predispose patients to suffer thiopurine-induced toxicity, and genotype-guided treatment has been shown to contribute to the prevention of thiopurine-induced toxicity, especially in the case of NUDT15 in Asians.

Keyphrases

end stage renal disease
high glucose
diabetic rats
oxidative stress
chronic kidney disease
newly diagnosed
drug induced
peritoneal dialysis
prognostic factors
emergency department
patient reported outcomes
adverse drug
electronic health record
replacement therapy