A Comparative Study of an Anti-Thrombotic Small-Diameter Vascular Graft with Commercially Available e-PTFE Graft in a Porcine Carotid Model.
Kyo Seon LeeMukhammad KayumovGladys A EmechebeDo-Wan KimHwa-Jin ChoYun-Jin JeongDong-Weon LeeJun-Kyu ParkChan-Hee ParkCheol-Sang KimFrancis O ObiweluozorIn Seok JeongPublished in: Tissue engineering and regenerative medicine (2022)
The PCL/PDO + 10%DY graft was well tolerated, and no adverse tissue reaction was observed in porcine carotid models during the short-term follow-up. Colonization of the graft by host endothelial and smooth muscle cells coupled with substantial extracellular matrix production marked the regenerative capability. Thus, this material may be an ideal substitute for vascular reconstruction and bypass surgeries. Long-term observations will be necessary to determine the anti-thrombotic and remodeling potential of this device.