Anti-SMN autoantibodies in mixed connective tissue disease are associated with a severe systemic sclerosis phenotype.
Hajar El KamouniDarya S JalaledinAlexandra AlbertSabrina HoaCaroline VoJosiane Bourré-TessierÉric RichJean-Richard GouletMartial KoenigGemma PérezMay Y ChoiYves TroyanovMinoru SatohMarvin J FritzlerJean-Luc SenécalOcéane Landon-CardinalPublished in: RMD open (2023)
Anti-SMN aAbs were present in 59% of our MCTD cohort. Their presence, especially at high-titres, was associated with a severe systemic sclerosis (scleroderma) phenotype including myositis, myocarditis and lower GI involvement.