PBPK/PD Modeling of Nifedipine for Precision Medicine in Pregnant Women: Enhancing Clinical Decision-Making for Optimal Drug Therapy.

Xinyang LiuWei WangJingsi ChenDunjin ChenYong TaoDefang Ouyang

Published in: Pharmaceutical research (2023)

Based on available literature data, the PBPK/PD model of Nifedipine in pregnancy demonstrated good predictive performance. It will help optimize individualized dosing of Nifedipine, improve treatment outcomes, and minimize the risk of adverse reactions in mothers and infants.

Keyphrases

pregnant women
decision making
pregnancy outcomes
systematic review
adverse drug
electronic health record
preterm birth
big data
emergency department
machine learning
bone marrow
data analysis
drug induced
smoking cessation