The renoprotective effects of Heme Oxygenase-1 during contrast-induced acute kidney injury in preclinical diabetic models.
Cassiane Dezoti da FonsecaMirian WatanabeSheila Marques Fernandes CoutoAlef Aragão Carneiro Dos SantosFernanda Teixeira BorgesMaria de Fatima Fernandes VattimoPublished in: Clinics (Sao Paulo, Brazil) (2021)
Our findings highlight the renoprotective effects of HO-1 in CI-AKI and preclinical diabetic models. Therefore, HO-1 ameliorates kidney dysfunction, reduces oxidative stress, and prevents cell necrosis.
Keyphrases
- oxidative stress
- cell therapy
- diabetic rats
- type diabetes
- wound healing
- acute kidney injury
- mouse model
- magnetic resonance
- high glucose
- single cell
- pi k akt
- dna damage
- ischemia reperfusion injury
- stem cells
- induced apoptosis
- mesenchymal stem cells
- endothelial cells
- computed tomography
- signaling pathway
- endoplasmic reticulum stress
- heat shock
- stress induced