High mutational concordance between primary colorectal tumors and associated pulmonary metastases.
Erin M BayleySaumil S DatarKyle G MitchellNicolas ZhouWayne L HofstetterReza J MehranRavi RajaramDavid C RiceJack A RothBoris SepesiStephen G SwisherAra A VaporciyanGarrett L WalshShanda H BlackmonJonathan M LoreeVan K MorrisMara B AntonoffPublished in: Journal of surgical oncology (2020)
Because high intertumoral genomic homogeneity exists, it may be reasonable to use primary CRC mutational profiles to guide prognostication and targeted therapy for PM. However, the possibility of de novo KRAS-mutant PM should be considered, particularly among patients previously treated with anti-EGFR therapy.