Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.

Jincai WenWenqing MuHui LiYulu YanXiaoyan ZhanWei LuoZhongxia WangWen KanJia ZhaoSiwen HuiPing HeShuanglin QinYingjie XuPing ZhangXiaohe XiaoGuang XuZhaofang Bai

Published in: Molecular medicine (Cambridge, Mass.) (2023)

Glab is a specific inhibitor of the cGAS-STING signaling pathway and may be used in the clinical therapy of cGAS-STING pathway-mediated autoimmune diseases.

Keyphrases

signaling pathway
multiple sclerosis
pi k akt
dendritic cells
epithelial mesenchymal transition
induced apoptosis
immune response
cell proliferation
smoking cessation