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Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria.

Angelo FreiMaite AmadoMatthew A CooperMark A T Blaskovich
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug-resistant S. aureus and E. coli. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.
Keyphrases
  • drug resistant
  • drug discovery
  • multidrug resistant
  • acinetobacter baumannii
  • escherichia coli
  • atomic force microscopy
  • mass spectrometry
  • silver nanoparticles