Multivariate genome wide association and network analysis of subcortical imaging phenotypes in Alzheimer's disease.

Xianglian MengJin LiQiushi ZhangFeng ChenChenyuan BianXiaohui YaoJingwen YanZhe XuShannon L RisacherAndrew J SaykinHong LiangLi Shennull null

Published in: BMC genomics (2020)

The statistical power of coupling MGAS with iPINBPA was higher than traditional GWAS method, and yielded new findings that were missed by GWAS. This study provides novel insights into the molecular mechanism of Alzheimer's Disease and will be of value to novel gene discovery and functional genomic studies.

Keyphrases

network analysis
genome wide association
copy number
cognitive decline
high resolution
small molecule
genome wide
high throughput
white matter
room temperature
multiple sclerosis
dna methylation
single cell
transcription factor