Age-related dysregulation of the retinal transcriptome in African turquoise killifish.
Steven BergmansNicole C L NoelLuca MasinEllen G HardingAleksandra M KrzywańskaJulie D De SchutterRajagopal AyanaChi-Kuo HuLutgarde ArckensPhilip A RuzyckiRyan B MacDonaldBrian S ClarkLieve MoonsPublished in: bioRxiv : the preprint server for biology (2024)
The aged killifish retina displays several ageing hallmarks, such as oxidative stress, gliosis and inflammageing, at the transcriptome level.Risk genes for neurodegenerative disorders show dysregulation in the old killifish retina.All vertebrate retinal cell types are present in the killifish retina.Transcriptional dysregulation in the aged killifish retina is observed across cell types.