Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis.
Pia LeeteRichard A OramTimothy J McDonaldBeverley M ShieldsClemens Zillernull nullAndrew T HattersleySarah J RichardsonNoel G MorganPublished in: Diabetologia (2020)
Among those with type 1 diabetes diagnosed under the age of 30 years, there are histologically distinct endotypes that correlate with age at diagnosis. Recognition of such differences should inform the design of future immunotherapeutic interventions designed to arrest disease progression.