Age-adjusted association of homologous recombination genes with ovarian cancer using clinical exomes as controls.

Kevin J ArvaiMaegan E RobertsRebecca I ToreneLisa R SussweinMegan L MarshallZhancheng ZhangNatalie J CarterLauren YackowskiErica S RinellaRachel T KleinKathleen S HruskaKyle Retterer

Published in: Hereditary cancer in clinical practice (2019)

The lack of association of PVs in BRIP1 with OC by ORAdj is inconsistent with some previous literature and current management recommendations, highlighted by the significantly older age of OC onset for BRIP1 PV carriers compared to non-carriers. By reporting ORAdj, this study presents associations that reflect more informed genetic contributions to OC when compared to traditional count-based methods.

Keyphrases

dna damage
dna repair
genome wide
systematic review
physical activity
gene expression
clinical practice
dna methylation
middle aged
copy number