Overdoses due to fentanyl and its analogues (F/FAs) push naloxone to the limit.
Joseph V PergolizziAlbert DahanJo Ann LeQuangRobert B RaffaPublished in: Journal of clinical pharmacy and therapeutics (2021)
As a competitive antagonist at μ-opioid receptors, naloxone is often a life-saving agent in cases of overdose caused by conventional opioids, but it may not be versatile or powerful enough to combat the rising tide of overdoses due to fentanyl and its illicit analogues, or in cases of overdose involving combinations of opioids and non-opioids.