Feasibility study of three-material decomposition in dual-energy cone-beam CT imaging with deep learning.

Objective. In this work, a dedicated end-to-end deep convolutional neural network, named as Triple-CBCT, is proposed to demonstrate the feasibility of reconstructing three different material distribution volumes from the dual-energy CBCT projection data. Approach. In Triple-CBCT, the features of the sinogram and the CT image are independently extracted and cascaded via a customized domain transform network module. This Triple-CBCT network was trained by numerically synthesized dual-energy CBCT data, and was tested with experimental dual-energy CBCT data of the Iodine-CaCl 2 solution and pig leg specimen scanned on an in-house benchtop system. Main results. Results show that the information stored in both the sinogram and CT image domains can be used together to improve the decomposition quality of multiple materials (water, iodine, CaCl 2 or bone) from the dual-energy projections. In addition, both the numerical and experimental results demonstrate that the Triple-CBCT is able to generate high-fidelity dual-energy CBCT basis images. Significance. An innovative end-to-end network that joints the sinogram and CT image domain information is developed to facilitate high quality automatic decomposition from the dual-energy CBCT scans.